What Is P-Shot Combination Therapy?
P-Shot combination therapy refers to pairing the PRP injection with complementary treatments to enhance and prolong results. The two most evidence-backed combinations are: P-Shot + VED (vacuum erection device) used post-procedure, and P-Shot + low-dose PDE5 inhibitors (like tadalafil/Cialis). Some clinics also combine P-Shot with low-intensity shockwave therapy (LiSWT) for enhanced tissue regeneration.
P-Shot + VED: The Most Important Combination
Using a vacuum erection device (VED) daily for 10 minutes, starting from day 3 post-treatment, is the most evidence-backed way to maximise P-Shot results. The VED creates a gentle stretch that encourages blood flow to PRP-stimulated tissue, promoting enhanced vascular growth. Patients who use VED consistently post-treatment typically report 20–40% better outcomes compared to those who don't.
P-Shot + Low-Dose PDE5 Inhibitors
Taking a low daily dose of tadalafil (2.5–5mg) in the weeks following P-Shot treatment can support the healing environment by maintaining penile blood flow. This approach, sometimes called 'penile rehabilitation', is widely used after prostatectomy and is increasingly recommended post-P-Shot. The combination of PRP-stimulated tissue growth with enhanced blood flow creates synergistic improvements.
Who Should Consider Combination Therapy?
Combination therapy is particularly recommended for: men with moderate-to-severe ED who need maximal results, post-prostatectomy patients, men with diabetic ED, and anyone who did not achieve full results from a P-Shot alone. Our doctors will discuss whether combination therapy is appropriate during your consultation and provide a personalised post-treatment protocol.