What Is Peyronie's Disease and How Does It Develop?
Peyronie's disease is a condition in which fibrous scar tissue (plaque) develops inside the penis, causing it to curve during erections — sometimes painfully. It develops gradually, often following injury to the penis during sexual activity, and affects an estimated 1–3% of adult men. Severe cases can make intercourse difficult or impossible and are often associated with erectile dysfunction.
How PRP May Help with Peyronie's
PRP injections deliver growth factors that have anti-fibrotic properties, meaning they can potentially break down or soften existing scar tissue and reduce further plaque formation. Studies have shown that PRP may reduce plaque size, decrease penile curvature, alleviate pain, and improve associated erectile dysfunction in Peyronie's patients. The treatment is typically given as a series of injections rather than a single treatment.
Clinical Evidence for PRP in Peyronie's
A 2016 study found that 39% of Peyronie's patients receiving intralesional PRP injections experienced a meaningful reduction in curvature. A 2020 review concluded that PRP is a promising minimally invasive option for Peyronie's disease, particularly in the early (active phase) of the condition. While evidence is promising, it is not yet as robust as for straightforward ED treatment.
What Peyronie's Patients Should Know Before Treatment
The P-Shot for Peyronie's tends to work best in the early phase of the disease (first 12 months) before the plaque fully hardens. Multiple sessions are often recommended, spaced 4–6 weeks apart. While P-Shot may reduce curvature, it may not fully straighten the penis in severe cases. A thorough consultation with a qualified urologist is essential before proceeding with PRP for Peyronie's.