Treatment guide
Evidence status: ExperimentalP-Shot PRP Treatment for Erectile Dysfunction
What is P-Shot?
P-Shot is a penile PRP procedure in which platelet-rich plasma prepared from the patient's own blood is injected into penile tissue. It is used by some clinics as a regenerative approach for selected men with erectile dysfunction. It is sometimes marketed as the Priapus Shot, penile PRP or the plasma shot. It is considered experimental, and suitability and expected benefit vary between patients.
Key fact: The 2026 EAU guideline says intracavernosal PRP for erectile dysfunction should be used only in a clinical-trial setting. (European Association of Urology, 2026; page updated )
This guide explains the procedure in plain language, who it may or may not suit, and what research does and does not show.
Private & confidential enquiry. You do not need to call.
Key takeaways
- Your own blood is processed to concentrate platelets, then injected after numbing. It is an outpatient procedure.
- Evidence is mixed. The 2026 European Association of Urology (EAU) guideline says intracavernosal PRP for erectile dysfunction should be used only in a clinical-trial setting.
- A specialist assessment decides whether it is relevant for you, and established options are discussed first.
What is P-Shot?
PRP stands for platelet-rich plasma. It is made from a sample of your own blood. Platelets release growth factors, which is why PRP is being studied in several areas of medicine.
In the P-Shot, the PRP is injected into penile tissue. The idea is that it may support tissue repair and blood flow. This is a proposed mechanism. It has not been proven to restore erections in people.
How is PRP prepared and the P-Shot performed?
The exact protocol is explained by the clinic at assessment. The usual stages are:
Assessment and consent
The urologist reviews your history and examines you, and explains the evidence, risks and alternatives. You sign written consent before treatment.
Blood sample
A small amount of blood is taken from your arm using a sterile technique.
PRP preparation
The blood is spun in a centrifuge. This separates the plasma and concentrates the platelets into platelet-rich plasma.
Numbing
Local anaesthetic or numbing cream is used so the injection is more comfortable.
Injection
The PRP is injected into penile tissue by the doctor. It is an outpatient procedure, so you go home the same day.
Aftercare
You receive written aftercare instructions, warning signs and a contact for questions.
Who may be suitable, and who may not
May be considered
Men with organic ED after assessment who understand that the treatment is experimental, have discussed established options and want to explore a regenerative approach.
Depends on the cause
Benefit may vary with the cause of ED. Severe nerve damage or advanced vascular disease may limit any effect. The doctor explains this at assessment.
May not be suitable
Active infection or skin lesions, bleeding disorders or blood-thinning medicines, low platelet count, current cancer treatment or a weakened immune system, or allergy to local anaesthetic.
Needs review first
Penile pain, curvature, a lump or suspected Peyronie's disease, and untreated heart disease, diabetes or hormonal problems should be assessed before any ED procedure.
P-Shot for erectile dysfunction: what the research shows
Some randomised trials report better erectile-function questionnaire scores after PRP than after placebo. A 2023 randomised placebo-controlled trial found no efficacy difference and no change in penile Doppler measures over six months. Reviews describe encouraging signals but also big differences in preparation, dose and study quality.
The 2026 European Association of Urology (EAU) guideline says intracavernosal PRP for erectile dysfunction should be used only in a clinical-trial setting. For that reason, the clinic discusses PRP as an experimental option and only after assessment.
P-Shot and erection quality
Men often ask whether PRP can improve hardness or help them keep an erection. In studies, such outcomes are measured with questionnaires and sometimes Doppler ultrasound. Results differ between studies. Suitability and expected benefit vary between patients and depend on the underlying cause.
P-Shot compared with other options
The most appropriate treatment depends on the underlying cause of ED.
| Treatment | Typical candidate | Invasiveness | Number of sessions | Recovery | Primary treatment concept | Clinical assessment required |
|---|---|---|---|---|---|---|
| P-Shot (PRP) | Selected men with organic ED after assessment | Minimally invasive (injection) | Protocol varies; confirmed at assessment | Usually short; instructions given by the clinician | Injected platelet-rich plasma, proposed to support tissue repair | Yes |
| Shockwave / EdSWT | Vasculogenic ED; some partial responders to tablets | Non-invasive (no injection) | Clinic protocol: 12 sessions over about 2 to 3 months | No downtime expected for most men; confirmed by the clinic | Low-intensity shockwaves, proposed to support blood-flow pathways | Yes |
| Stem Cell | Selected men when established options were unsuitable or ineffective | Minimally invasive; may involve cell collection | Individualised; explained at assessment | Depends on the procedure; confirmed by the clinic | Cell-based preparation, proposed to support tissue repair | Yes |
| Exosome | Men asking about an investigational option | Minimally invasive if offered | Not established; confirmed only if offered | Confirmed if offered | Cell-derived vesicles, proposed to support repair signalling | Yes |
| PDE5 medication (e.g. sildenafil, tadalafil) | Many men with ED, unless contraindicated (for example with nitrates) | Non-invasive (tablet) | Ongoing, as needed or daily depending on the medicine | None | Increases the blood-flow response to sexual stimulation | Yes (prescription, with a health check) |
| Penile injections (e.g. alprostadil) | Men for whom tablets are unsuitable or ineffective | Self-injection after training | As needed before sex | None | Medicine injected into the penis to produce an erection | Yes (training and dose setting) |
| Penile implant | Severe or refractory ED after other options | Surgical | One operation | Surgical recovery; instructions given by the surgeon | A device placed in the penis that allows an erection | Yes (surgical assessment) |
A guide for discussion with your urologist, not a ranking or recommendation. Regenerative therapies are experimental or investigational for ED.
P-Shot vs other regenerative approaches
Recovery and what to expect afterwards
Most men go home the same day. Some tenderness, bruising or swelling in the first days is common. The doctor gives specific instructions on activity, including when to resume sexual activity.
Possible side effects
Reported adverse events in studies have generally been minor, but trials are too small to define uncommon risks. Using your own blood avoids rejection but does not make an injection risk-free.
Common
Temporary pain, tenderness, bruising, redness or swelling at the injection site.
Learn more →Bleeding
Bleeding or a haematoma can occur, and risk may be higher with blood thinners or bleeding disorders.
Infection
Any injection can cause infection if sterile technique is not followed.
Seek urgent help
Fever, spreading redness, pus, severe or worsening pain, heavy bleeding, difficulty passing urine or an erection lasting more than four hours.
When might I notice a change?
In published studies, outcomes were usually assessed over weeks to months, for example up to six months. No fixed timeline can be promised, and some men notice no change. The clinic explains how it measures progress and what follow-up it offers.
Your physician
Dr. Niyazi Umut Özdemir
Urological Surgeon, UZ Clinic Antalya
Responsible for assessment and treatment planning at the clinic, with a clinical focus on male sexual health and penile rehabilitation.
Rated 4.5 on Google (47 reviews, as of 2 Oct 2026)Qualifications
- • Medical education at Ege University
- • Specialisation in urology
- • Turkish Association of Urology board certification
- • Clinical practice in Antalya, Turkey
Clinical focus
- • Erectile dysfunction assessment and treatment planning
- • Penile rehabilitation
- • Vasculogenic (blood-flow related) erectile dysfunction
- • Shockwave therapy, PRP and regenerative approaches
Education and roles
- • Ege University Faculty of Medicine (2000); urology specialisation, Ege University (2005)
- • Head of the Antalya branch, CİSED
Professional memberships
- • Turkish Urological Association
- • Society of Urological Surgery (Ürolojik Cerrahi Derneği)
- • European Association of Urology (EAU)
- • Turkish Andrology Association
- • Aegean Urological Association (Ege Üroloji Derneği)
- • Ankara Urologists Association
Ask the urologist about your case
Send your history and the clinic will advise which options may be relevant. Suitability is decided after medical assessment.
Frequently asked questions
What is the Priapus Shot?
"Priapus Shot" is a brand name sometimes used for penile PRP injection, the same type of procedure described on this page. The medical term is intracavernosal platelet-rich plasma injection. It is experimental for erectile dysfunction.
Is the P-Shot proven to treat erectile dysfunction?
No. Some trials report improvement, while others found no difference from placebo. The 2026 European Association of Urology (EAU) guideline says intracavernosal PRP for erectile dysfunction should be used only in a clinical-trial setting.
Does the P-Shot hurt?
Numbing is used before the injection. Many men describe mild discomfort, but experiences differ.
Is the P-Shot permanent?
No permanent effect can be promised. If there is a benefit, how long it lasts is uncertain and varies between patients.
Is the P-Shot safe?
Reported side effects have mostly been minor, but studies are small and long-term data are limited. The doctor explains the risks and who should not have it.
Does the P-Shot increase penis size?
No. P-Shot is not a penile-enlargement treatment and the clinic does not claim it enlarges the penis.
Can I have P-Shot together with other treatments?
Sometimes the doctor may discuss combinations, but evidence is limited. Treatment is decided after assessment.
What is the difference between P-Shot and PRP for ED?
P-Shot is a brand-style name for penile PRP injection. The medical term is intracavernosal platelet-rich plasma injection.
Sources
- EAU Guidelines on Sexual and Reproductive Health: Management of Erectile DysfunctionEuropean Association of Urology, 2026 · Guideline
- Erectile Dysfunction: AUA GuidelineAmerican Urological Association, 2018 · Guideline
- PRP Intracavernosal Injections for Primary Organic ED: Systematic Review and Meta-analysisInternational Journal of Impotence Research / PubMed, 2024 · Systematic review
- Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Randomised Placebo-controlled TrialThe Journal of Urology / PubMed, 2023 · Randomised trial
- Platelet-Rich Plasma Improves Erectile Function: A Randomised Placebo-controlled TrialThe Journal of Sexual Medicine / PubMed, 2021 · Randomised trial
Related guides
Send your case for confidential review
You do not need to know which treatment you need. Share a few details and the clinic can advise which options may be relevant to your case.
- 1. Send your caseAbout 2 minutes, private.
- 2. Coordinator contacts youBy WhatsApp, phone or email.
- 3. Doctor assessmentThe urologist decides suitability.
Private & confidential enquiry. You do not need to call.
This page provides general information and does not diagnose ED or decide whether a treatment is suitable for you. Suitability and expected benefit vary between patients and are decided after medical assessment. Treatments described as experimental or investigational are discussed with full informed consent. Seek urgent care for chest pain, new neurological symptoms, penile injury or an erection lasting more than four hours.